Enhancing cell infiltration of electrospun fibrous scaffolds in tissue regeneration
نویسندگان
چکیده
منابع مشابه
In vitro and in vivo evaluation of electrospun PCL/PMMA fibrous scaffolds for bone regeneration
Scaffolds were fabricated by electrospinning using polycaprolactone (PCL) blended with poly(methyl methacrylate) (PMMA) in ratios of 10/0, 7/3, 5/5 and 3/7. The PCL/PMMA ratio affected the fiber diameter, contact angle, tensile strength and biological in vitro and in vivo properties of the scaffolds, and the 7/3 ratio resulted in a higher mechanical strength than 5/5 and 3/7. In vitro cytotoxic...
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objective: the development of combining mesenchymal stem cells (mscs) with surface modified three-dimensional (3d) biomaterial scaffold provides a desirable alternative for replacement of damaged and diseased tissue. nanofibrous scaffolds serve as suitable environment for cell attachment and proliferation due to their similarity to the physical dimension of the natural extracellular matrix. in ...
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Surface properties of biomaterials play a major role in the governing of cell functionalities. It is well known that mechanical, chemical and nanotopographic cues, for example, influence cell proliferation and differentiation. Here, we present a novel coating protocol to produce hierarchically engineered fibrous scaffolds with tailorable surface characteristics, which mimic bone extracellular m...
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Schwartz. In 2007, I came to Dr. Haifeng Chen's lab and started my journey of biomedical engineering. In my first four years of PhD study, Dr. Chen has exposed me to many different perspectives of being a good researcher, like how to think and work independently, and be creative. When the GaTech/PKU/Emory joint program first started, Dr. Chen was so supportive. Thanks to his support and referen...
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The structural and mechanical properties of tissue engineered environments are crucial for successful cellular growth and tissue repair. Electrospinning is gaining wide attention for the fabrication of tissue engineered scaffolds, but the small pore sizes of these scaffolds limit cell infiltration and construct vascularization. To address this problem, we have combined electrospinning with phot...
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ژورنال
عنوان ژورنال: Bioactive Materials
سال: 2016
ISSN: 2452-199X
DOI: 10.1016/j.bioactmat.2016.07.001